O‘TKIR ISHEMIK INSULTDA ENDOVASKULYAR REPERFUZIYA VA ERTA REABILITATSIYA: TASVIRLASHGA ASOSLANGAN INDIVIDUAL YONDASHUV

Maqola yon paneli

PDF
Nashr qilingan: 2026-05-05
DOI: https://doi.org/10.66073/researchfocus.v5i4.2324
Kalit so‘zlar:
O‘tkir ishemik insult, Endovaskulyar reperfuziya, Mexanik trombektomiya Intravenoz tromboliz, Erta reabilitatsiya, Neyroplastiklik, Rekanalizatsiya, Neyrointerventsiya Insult natijalari, Tasvirlashga asoslangan terapiya

Maqolaning asosiy mazmuni

Kilichev Farruh Ahmadovich
Respublika ixtisoslashtirilgan ilmiy-amaliy kardiologiya tibbiyot markazining Samarqand; viloyati mintaqaviy filiali, Samarqand Davlat Tibbiyot universiteti, O‘zbekiston, Samarqand
Yarmuhamedova Nargiza Anvarovna
Respublika ixtisoslashtirilgan ilmiy-amaliy kardiologiya tibbiyot markazining Samarqand; viloyati mintaqaviy filiali, Samarqand Davlat Tibbiyot universiteti, O‘zbekiston, Samarqand
Aliyev Mansur
Respublika ixtisoslashtirilgan ilmiy-amaliy kardiologiya tibbiyot markazining Samarqand; viloyati mintaqaviy filiali, Samarqand Davlat Tibbiyot universiteti, O‘zbekiston, Samarqand

Abstrak

O‘tkir ishemik insult dunyo bo‘yicha o‘lim va uzoq muddatli nogironlikning asosiy sabablaridan biri bo‘lib qolmoqda. To‘qima plasminogen aktivatori bilan intravenoz tromboliz insultni erta bosqichda samarali boshqarishni sezilarli darajada yaxshilagan bo‘lsa-da uning samaradorligi tor terapevtik oynasi va katta tomir yopilishlarida to‘liq rekanalizatsiya bo‘lmasligi bilan cheklangan. So‘nggi paytlarda endovaskulyar reperfuziya texnikasidagi ilg‘or yutuqlar davolash sohasini tubdan o‘zgartirdi, bu esa tomirlarning muvaffaqiyatli rekanalizatsiya darajasini oshirish va klinik natijalarni yaxshilash imkonini berdi. Zamonaviy yondashuvlar jumladan, mexanik trombektomiya, aspiratsion trombektomiya va intraarterial tromboliz, ayniqsa intravenoz trombolitik terapiya bilan birgalikda qo‘llanganda yuqori samaradorlikni namoyon qilmoqda. Shuningdek, yangi fibrinolitik vositalarning rivojlanishi va ultratovush yordamida tromboliz kabi yordamchi usullar terapevtik imkoniyatlarni yanada kengaytirdi. Reperfuziya strategiyalari bilan bir qatorda, o’tkir va akut bosqichda reabilitatsiyani erta boshlash nevrologik tiklanishni yaxshilash, neyroplastiklikni rag‘batlantirish va uzoq muddatli nogironlikni kamaytirishda muhim rol o‘ynaydi. Ilg‘or endovaskulyar aralashuvlarni erta reabilitatsiya bilan integratsiyalash o’tkir ishemik insultni boshqarishda kompleks va bemor markazli yondashuvni tashkil qiladi. Kelajakda individual, tasvirlashga asoslangan davolash strategiyalari va ko‘p tarmoqli yondashuvlar funksional natijalarni optimallashtirish va terapevtik oynalarni kengaytirishga e’tibor qaratadi.

Maqola tafsilotlari

Nashr

Jild 5 Nomeri 4 (2026): Research Focus International Scientific Journal. 5-tom, 4-son (2026)

Bo'lim

14.00.00 – Tibbiyot fanlari
Creative Commons litsenziyasi

Ushbu asar Creative Commons Attribution 4.0 International litsenziyasi asosida litsenziyalangan.

Qanday iqtibos keltirish kerak

O‘TKIR ISHEMIK INSULTDA ENDOVASKULYAR REPERFUZIYA VA ERTA REABILITATSIYA: TASVIRLASHGA ASOSLANGAN INDIVIDUAL YONDASHUV. (2026). Research Focus International Scientific Journal, 5(4), 193-200. https://doi.org/10.66073/researchfocus.v5i4.2324

Adabiyotlar

Bernhardt, J., Godecke, E., Johnson, L., & Langhorne, P. (2016). Early rehabilitation after stroke. Current Opinion in Neurology, 30, 48–

https://doi.org/10.1097/wco.0000000000000404

Bhaskar, S., Stanwell, P., Cordato, D., Attia, J., & Levi, C. (2018). Reperfusion therapy in acute ischemic stroke: dawn of a new era?. BMC Neurology

https://doi.org/10.1186/s12883-017- 1007-y

Campbell, B., Mitchell, P., Kleinig, T., Dewey, H., Churilov, L., Yassi, N., Yan, B., Dowling, R. Parsons, M., Oxley, T., Wu, T., Brooks, M., Simpson, M., Miteff, F., Levi, C., Krause, M. Harrington, T., Faulder, K., Steinfort, B., Priglinger, M., Ang, T., Scroop, R., Barber, P. McGuinness, B., Wijeratne, T., Phan, T., Chong, W., Chandra, R., Bladin, C., Badve, M., Rice, H. De Villiers, L., , H., Desmond, P., Donnan, G., & Davis, S. (2015). Endovascular therapy for ischemic stroke with perfusion-imaging selection.. The New England journal of medicine, 372 11 1009-

https://doi.org/10.1056/nejmoa1414792

Coleman, E., Moudgal, R., Lang, K., Hyacinth, H., Awosika, O., Kissela, B., & Feng, W. (2017). Early Rehabilitation After Stroke: a Narrative Review. Current Atherosclerosis Reports, 19, 1-

https://doi.org/10.1007/s11883-017-0686-6

Galimov, A., Stenkina, N., Gaikina, E., Shafikova, E., Bashirova, A., Yapparov, A., Amirkhanyan A., Rozhkov, M., Morozov, N., Davletbaeva, N., Gimranova, N., Yamgurova, R. Shagiakhmetova, D., Sultanmuratov, I., & Reshetnikova, A. (2025). Modern approaches to the management of early rehabilitation period after ischemic stroke. Medical and Social Expert Evaluation and Rehabilitation. https://doi.org/10.17816/mser680937

Hasan, T., Hasan, H., & Kelley, R. (2021). Overview of Acute Ischemic Stroke Evaluation and Management. Biomedicines

https://doi.org/10.3390/biomedicines9101486

He, Y., Nie, X., He, T., Qi, X., Chen, Z., Duan, W., Wei, Y., Liu, X., & Liu, Y. (2022). Impact of Early Rehabilitation on Outcomes in Patients With Acute Ischemic Stroke After Endovascular Treatment. Frontiers in Neurology

https://doi.org/10.3389/fneur.2022.877773

Lou, Y., Liu, Z., Ji, Y., Cheng, J., Zhao, C., & Li, L. (2024). Efficacy and safety of very early rehabilitation for acute ischemic stroke: a systematic review and meta-analysis. Frontiers in Neurology

https://doi.org/10.3389/fneur.2024.1423517

Mohammaden, M., Haussen, D., & Nogueira, R. (2021). Therapeutic Advancements in the Endovascular Management of Acute Ischemic Stroke. Stroke: Vascular and Interventional Neurology. https://doi.org/10.1161/svin.121.000168

Molina, C., & Saver, J. (2005). Extending Reperfusion Therapy for Acute Ischemic Stroke: Emerging Pharmacological, Mechanical, and Imaging Strategies. Stroke, 36, 2311-2320. https://doi.org/10.1161/01.str.0000182100.65262.46

Mouyal, S., Diaz, H., Zuber, M., Tamazyan, R., Romulus, A., Désilles, J., Olivot, J., Mazighi, M. & Maïer, B. (2025). Endovascular therapy for acute ischemic stroke: From a decade of trials to the next frontier.. Med, 100889. https://doi.org/10.1016/j.medj.2025.100889

Nguyen, T., Abdalkader, M., Fischer, U., Qiu, Z., Nagel, S., Chen, H., Miao, Z., & Khatri, P. (2024). Endovascular management of acute stroke. The Lancet, 404, 1265-1278. https://doi.org/10.1016/s0140-6736(24)01410-7

Tong, Y., Ding, Y., Han, Z., Duan, H., & Geng, X. (2023). Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry. Brain Circulation, 9, 201 - 204. https://doi.org/10.4103/bc.bc_33_23

Wang, F., Zhang, S., Zhou, F., Zhao, M., & Zhao, H. (2021). Early physical rehabilitation therapy between 24 and 48 h following acute ischemic stroke onset: a randomized controlled trial. Disability and Rehabilitation, 44, 3967 - 3972. https://doi.org/10.1080/09638288.2021.1897168

Wang, Q., Liu, N., Simo, L., , Q., & Li, C. (2025). A narrative review of reperfusion therapy in acute ischemic stroke: Emerging advances, current challenges, and future directions. Brain Circulation, 11, 187 - 199. https://doi.org/10.4103/bc.bc_161_24

Wei, X., Sun, S., Zhang, M., & Zhao, Z. (2024). A systematic review and meta-analysis of clinical efficacy of early and late rehabilitation interventions for ischemic stroke. BMC Neurology

https://doi.org/10.1186/s12883-024-03565-8

Widimsky, P., Snyder, K., Sulženko, J., Hopkins, L., & Štětkářová, I. (2022). Acute ischaemic stroke: recent advances in reperfusion treatment. European Heart Journal, 44, 1205 - 1215. https://doi.org/10.1093/eurheartj/ehac684

Wu, W., Zhou, C., Wang, Z., Chen, G., Chen, X., Jin, H., & He, D. (2020). Effect of Early and Intensive Rehabilitation after Ischemic Stroke on Functional Recovery of the Lower Limbs: A Pilot, Randomized Trial.. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 104649. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104649

Xiong, Y., Wakhloo, A., & Fisher, M. (2022). Advances in Acute Ischemic Stroke Therapy.. Circulation research, 130 8, 1230-1251. https://doi.org/10.1161/circresaha.121.319948