CORRELATION OF THE PATHOMORPHOLOGICAL FORM OF TOXIC GOITER WITH THE LEVEL OF ANTIBODIES TO THYROID PEROXIDASE

Abstract

The results of the treatment of 191 patients with toxic forms of goiter are presented. A study of the prognostic factors of the surgical treatment of patients with toxic forms of goiter established that the main cause of goiter recurrence was the performance of organ-preserving operations to the extent of subtotal resection of the thyroid gland (recurrence 17.2%) and hemithyroidectomy (recurrence 21.7%) in follicular colloid goiter with signs of hyperfunction (recurrence 24.2%). An increase in the number of recurrences depending on the duration of the disease and a decrease in the recurrence rate with an increase in the extent of the operation were established. The choice of the extent of the operation in toxic forms of goiter should be based on prognostic factors — the level of antibodies to thyroid peroxidase, whose values correlate with the pathomorphological form of toxic goiter. The proposed treatment-and-diagnostic algorithm made it possible to improve the quality of treatment by reducing the rate of unsatisfactory results in the late postoperative period from 16.5% to 3.6%.