IDENTIFICATION OF EARLY DISORDERS OF GLOMERULAR FILTRATION RATE IN PATIENTS WITH INSULIN RESISTANCE DEPENDING ON THE DEGREE OF OBESITY
Main Article Content
Abstract
Chronic heart failure (CHF) remains one of the most pressing medical and socio-economic problems, despite significant progress in treatment, since the prognosis of these patients remains unfavorable. Intensive study of the relationship between the pathology of the cardiovascular system and the kidneys led to the creation of the concept of cardiorenal syndrome.
Article Details
Issue
Section

This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
Gregg EW, Jakicic JM, Blackburn G, Bloomquist P, Bray GA, Clark JM, et al. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol (2016) 4(11):913–21.
Rosenstock J, Wysham C, Frías JP, Kaneko S, Lee CJ, Fernández Landó L, et al. Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. Lancet (2021) 398(10295):143–55. doi: 10.1016/S0140-6736(21)01324-6
Шилов Е.М. и др.Новые подходы к лечению больных хронической болезнью почек и метаболическим синдромом // Клиническая нефрология. 2012. № 2. С. 72–76.)
Friedman AN, Kaplan LM, le Roux CW, Schauer PR. Management of obesity in adults with CKD. J Am Soc Nephrology (2021) 32(4):777–90. doi: 10.1681/ASN.2020101472
Tesauro M, Mascali A, Franzese O, Cipriani S, Cardillo C, Di Daniele N. Chronic kidney disease, obesity, and hypertension: the role of leptin and adiponectin. Int J Hypertens (2012) 2012:943605. doi: 10.1155/2012/943605
Baylis D, Bartlett DB, Patel HP, Roberts HC. Understanding how we age: insights into inflammaging. Longevity Healthspan (2013) 2(1):8. doi: 10.1186/2046-2395-2-8
Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med (1995) 122(7):481–6. doi: 10.7326/0003-4819-122- 7-199504010-00001
Ahima RS. Connecting obesity, aging and diabetes. Nat Med (2009) 15(9):996–7. doi: 10.1038/nm0909-996
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, et al. Fat tissue, aging, and cellular senescence. Aging Cell (2010) 9(5):667–84. doi: 10.1111/j.1474- 9726.2010.00608.x
Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, et al. Senolytic drugs: Reducing senescent cell viability to extend health span. Annu Rev Pharmacol Toxicol (2021) 61:779–803. doi: 10.1146/annurev-pharmtox-050120-105018
Lair B, Laurens C, Van Den Bosch B, Moro C. Novel insights and mechanisms of lipotoxicity-driven insulin resistance. Int J Mol Sci [Internet] (2020) 21(17). doi: 10.3390/ijms21176358
Palmer AK, Tchkonia T, Kirkland JL. Targeting cellular senescence in metabolic disease. Mol Metab (2022) 66:101601. doi: 10.1016/j.molmet.2022.101601
Tzanavari T, Giannogonas P, Karalis KP. TNF-α and obesity. Current Directions in Autoimmunity (2010) 11:145–156. doi: 10.1159/000289203
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature (1997) 389(6651):610–4. doi: 10.1038/39335
Lim CC, Teo BW, Tai ES, Lim SC, Chan CM, Sethi S, et al. Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in Asian adults. PloS One (2015) 10(3):e0122009. doi: 10.1371/journal.pone.0122009
Menon V, Li L, Wang X, Greene T, Balakrishnan V, Madero M, et al. Adiponectin and mortality in patients with chronic kidney disease. J Am Soc Nephrology (2006) 17(9):2599. doi: 10.1681/ASN.2006040331 CrossRef Full Text | Google Scholar
Porrini E., Bayes B., Diaz Juan M. et al. Hyperinsulinemia and hyperfiltration in renal transplantation // Transplantation. 2009. Vol. 87. № 2. P. 274–279.
Suh SH, Oh TR, Choi HS, Kim CS, Lee J, Oh YK, et al. Association of high serum adiponectin level with adverse cardiovascular outcomes and progression of coronary artery calcification in patients with pre-dialysis chronic kidney disease. Front Cardiovasc Med (2021) 8:789488. doi: 10.3389/fcvm.2021.789488PubMed Abstract | CrossRef Full Text | Google Scholar
Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J, Hamilton MP, et al. Systemic fate of the adipocyte-derived factor adiponectin. Diabetes (2009) 58(9):1961–70. doi: 10.2337/db08-1750
Агабабян Ирина Рубеновна and Юсупова Зумрад Кадамбоевна. Сурункали буйрак етишмовчилиги билан боғлиқ сурункали юрак етишмовчилигининг клиник хусусиятлари. Журнал Проблемы биологии и медицины. 2022. № 6 (140)(декабрь. 2022), 26–30.