VINCRISTINE-INDUCED NEUROPATHY

Main Article Content

Gulyamova Durdona Nasriddinovna
Abduraxmonova Nigora
Matyakubova Xonzoda Bekturdiyevna

Abstract

Vincristine neuropathy is one of the most common and significant complications of chemotherapy involving vincristine. It manifests itself predominantly in the form of peripheral sensory and motor disorders, which substantially affects the quality of life of patients and may limit the continuation of treatment. The article considers the clinical manifestations, pathogenetic mechanisms, risk factors, diagnostic methods and approaches to the prevention and treatment of vincristine neuropathy. The need for further research aimed at the development of effective neuroprotective strategies and the improvement of the management of patients receiving vincristine therapy is noted.

Article Details

Section

14.00.00 – Medical sciences

How to Cite

VINCRISTINE-INDUCED NEUROPATHY. (2025). Research Focus International Scientific Journal, 4(4), 278-280. https://doi.org/10.66073/researchfocus.v4i4.1594

References

Verstappen, C. C. P., Heimans, J. J., Hoekman, K., Postma, T. J. (2003). Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs, 63(15), 1549–1563.

Cavaletti, G., Marmiroli, P. (2010). Chemotherapy-induced peripheral neurotoxicity. Current Opinion in Neurology, 23(5), 566–575.

Gomber, S., Dewan, P., Chhonker, D. (2010). Vincristine induced neurotoxicity: Diagnosis and management. Indian Journal of Pediatrics, 77(6), 643–646.

Park, S. B., Goldstein, D., Krishnan, A. V., Lin, C. S. Y., Friedlander, M. L., Kiernan, M. C. (2013). Chemotherapy-induced peripheral neurotoxicity: a critical analysis. CA: A Cancer Journal for Clinicians, 63(6), 419–437.

Verstappen, C. C. P., Postma, T. J., Hoekman, K., Heimans, J. J. (2005). Peripheral neuropathy due to chemotherapy: A review on the pathophysiology and therapeutic options. European Journal of Cancer, 41(3), 437–445.

Starobova, H., Vetter, I. (2017). Pathophysiology of chemotherapy-induced peripheral neuropathy. Frontiers in Molecular Neuroscience, 10, 174.

Windebank, A. J., Grisold, W. (2008). Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System, 13(1), 27–46.

Grisold, W., Cavaletti, G., Windebank, A. J. (2012). Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro-Oncology, 14(suppl_4), iv45–iv54.