GENETIC PREDISPOSITION TO PERIODONTAL DISEASES: MYTH OR REALITY?
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Abstract
Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent oral health conditions worldwide. While bacterial infections are considered the primary cause, increasing evidence suggests a genetic component in disease susceptibility. This article explores the role of genetic predisposition in periodontal diseases through a comprehensive analysis of family-based studies, twin studies, genome-wide association studies (GWAS), and epigenetic influences. The findings highlight that while genetics play a role, environmental and behavioral factors significantly modulate disease expression. The implications of genetic research for personalized periodontal treatment are also discussed.
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References
de Brito, G. B., Scarel-Caminaga, R. M., Trevilatto, P. C., & de Souza, A. P. (2019). The role of vitamin D receptor polymorphisms in periodontal disease: A systematic review. Journal of Periodontal Research, 54(3), 195-206.
Hajishengallis, G., & Chavakis, T. (2021). Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nature Reviews Immunology, 21(6), 426-440.
Kornman, K. S., Crane, A., Wang, H. Y., et al. (1997). The interleukin-1 genotype as a severity factor in adult periodontal disease. Journal of Clinical Periodontology, 24(1), 72-77.
Michalowicz, B. S., Diehl, S. R., Gunsolley, J. C., et al. (2000). Evidence of a substantial genetic basis for risk of adult periodontitis. Journal of Periodontology, 71(11), 1699-1707.
Tobón-Arroyave, S. I., Isaza-Guzmán, D. M., Restrepo-Cadavid, E. M., et al. (2005). Tumor necrosis factor-alpha gene polymorphism and its relationship with periodontal disease in a Colombian population. Journal of Periodontal Research, 40(4), 230-235.
Loos, B. G., & Van Dyke, T. E. (2020). The role of inflammation and genetics in periodontal disease. Periodontology 2000, 83(1), 26-39.
Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017). Periodontal diseases. Nature Reviews Disease Primers, 3(1), 17038.
Offenbacher, S., Barros, S. P., & Beck, J. D. (2008). Rethinking periodontal inflammation. Journal of Periodontology, 79(8 Suppl), 1577-1584.