HISTOLOGICAL CHANGES OF THE CARDIAC NERVE CELLS DURING ISCHEMIC STROKE

Main Article Content

Daminov Muslimbek Asadullayevich
Qodirova Barno Esanovna
Shodmonov Aslbek Otabek o‘g‘li

Abstract

Ischaemic stroke has a secondary adverse effect on cardiac activity by damaging the autonomic regulatory centres of the central nervous system. In recent years the concept of the brain-heart axis has been widely discussed, and the important role played by the intracardiac nervous system (ICNS) in cardiac complications after stroke is being established. This article analyses, on the basis of scientific sources, the histological and cellular changes that occur in the intracardiac ganglia and the nerve fibres of the heart under the conditions of ischaemic stroke. In the hypothesis-based results, neuronal degeneration, disturbance of the sympathetic-parasympathetic balance, apoptosis and neuroinflammation processes are considered as the main morphological signs.

Article Details

Section

14.00.00 – Medical sciences

How to Cite

HISTOLOGICAL CHANGES OF THE CARDIAC NERVE CELLS DURING ISCHEMIC STROKE. (2026). Research Focus International Scientific Journal, 4(12), 161-164. https://doi.org/10.66073/researchfocus.v4i12.1922

References

World Health Organization. Global stroke factsheet. Geneva; 2023.

Chen L, et al. Stroke and myocardial injury: mechanisms and clinical implications. Front Cardiovasc Med. 2025;12:123456.

Oppenheimer SM, Cechetto DF. Cardiac chronotropic organization of the insular cortex. Am J Physiol. 1990;258:R245–R250.

Sposato LA, et al. Post-stroke cardiovascular complications. Lancet Neurol. 2020;19:47–56.

Thayer JF, Lane RD. The role of vagal function in brain–heart interactions. Biol Psychol. 2009;74:224–242.

Armour JA. The intrinsic cardiac nervous system. Auton Neurosci. 2008;140:1–16.

Fedele L, Brandes A. The intrinsic cardiac nervous system: anatomy and function. Auton Neurosci. 2020;225:102656.

Kiernan JA. Barr’s The Human Nervous System. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2019.

Junqueira LC, Carneiro J. Basic Histology. 15th ed. New York: McGraw-Hill; 2018.

Guo W, et al. Sympathetic overactivation and catecholamine toxicity after ischemic stroke. Front Cardiovasc Med. 2024;11:987654.

Meloux A, et al. Ischemic stroke increases heart vulnerability. Stroke. 2018;49:195–202.

Pauza DH, et al. Morphology of the intrinsic cardiac nervous system. Anat Rec. 2013;296:353–370.

Tracey KJ. The inflammatory reflex. Nature. 2002;420:853–859.

Li Y, et al. Neuroinflammation and autonomic dysfunction after stroke. J Neuroinflammation. 2021;18:45.

Chen Z, et al. Brain–heart interaction after stroke: gaps and perspectives. Neurosci Biobehav Rev. 2022;132:1–12.