LEUKOENCEPHALOPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL).

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Published: 2025-05-05
DOI: https://doi.org/10.66073/researchfocus.v4i4.1593
Keywords:
leukoencephalopathy, acute lymphoblastic leukaemia (ALL), paediatric oncology, neurotoxicity, complications of chemotherapy, methotrexate, diagnosis, prevention, central nervous system

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Gulyamova Durdona Nasriddinovna
Tashkent Institute of Postgraduate Medical Education, Department of Pediatric Neurology
Abduraxmonova Nigora
Center for Pediatric Hematology, Oncology and Clinical Immunology
Matyakubova Xonzoda Bekturdiyevna

Abstract

Leukoencephalopathy is a severe pathology characterised by damage to the white matter of the central nervous system, which often develops in children with acute lymphoblastic leukaemia (ALL) and in the course of its treatment. The risk of leukoencephalopathy in patients with ALL is associated with cytostatic chemotherapy, especially with such drugs as methotrexate. Early detection and effective treatment of this complication are of great importance for improving outcomes, minimising neurological disorders and maintaining the quality of life of children. The article analyses the pathogenesis, clinical manifestations, diagnostic methods and preventive measures of leukoencephalopathy. The importance of an individual approach and interdisciplinary management is also emphasised in this case.

Article Details

Issue

Vol. 4 No. 4 (2025): Research Focus International Scientific Journal. Volume 4, Issue 4 (2025)

Section

14.00.00 – Medical sciences
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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

LEUKOENCEPHALOPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). (2025). Research Focus International Scientific Journal, 4(4), 276-277. https://doi.org/10.66073/researchfocus.v4i4.1593

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