VITAMIN D LEVEL AND ITS RELATIONSHIP WITH CYTOKINE LEVEL IN BRONCHO-OBSTRUCTIVE SYNDROME IN CHILDREN

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Turayeva Nafisa Omonovna
Khamzaeva Kamina Azizovna

Abstract

The aim of the study was to investigate the effect of vitamin D on the course of broncho-obstructive syndrome in children and to determine its relationship with cytokine status. The study involved 86 patients aged 3 to 15 years with acute obstructive bronchitis, recurrent obstructive bronchitis and bronchial asthma. The patients underwent a single set of diagnostic studies: clinical examination, immunological examination, and a study of vitamin D levels in blood serum. The results of the study showed that vitamin D deficiency was accompanied by the development of secondary immune deficiency.

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How to Cite
Omonovna, T. N., & Azizovna, K. K. (2026). VITAMIN D LEVEL AND ITS RELATIONSHIP WITH CYTOKINE LEVEL IN BRONCHO-OBSTRUCTIVE SYNDROME IN CHILDREN. Research Focus International Scientific Journal, 5(5), 194–200. Retrieved from https://refocus.uz/index.php/rf/article/view/2273
Section
14.00.00 – Medical sciences

References

Belykh N. A. Modern approaches to diagnostics and therapy of broncho-obstructive syndrome of infectious genesis in children / N. A. Belykh, L. A. Zalivnaya // Actual Infectology. — 2015. — Vol. 6, No.

Yulish E. I. On risk factors for the development of broncho-obstructive syndrome in young children / E. I. Yulish, Yu. A. Soroka, O. E. Chernysheva // Child Health. — 2012. — Vol. 41 No.

Gromova O. A., Torshin I. Yu. Vitamin D — a paradigm shift. — M.: GEOTAR-Media, 2017. — 568 p. ISBN: 978-5-9704-4058-

Schrumpf J. A., Amatngalim G. D., Veldkamp J. B., Verhoosel R. M., Ninaber D. K., Ordonez S. R., van der Does A. M., Haagsman H. P., Hiemstra P. S. Proinflammatory cytokines impair vitamin D-induced host defense in cultured airway epithelial cells // Am. J. Respir. Cell Mol. Biol. — 2017, Feb

DOI: 10.1165/rcmb.2016-0289OC.

Aryan Z., Rezaei N., Camargo C. A. Jr. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: a systematic review and meta-analysis // Int. Rev. Immunol. — 2017. — Vol. 36, No.

DOI: 10.1080/08830185.2016.1272600.

Sundaram M. E., Coleman L. A. Vitamin D and influenza // Adv. Nutr. — 2012. — Vol. 3, No.

— P. 517–525. DOI: 10.3945/an.112.002162.

Lang P. O., Samaras D. Aging adults and seasonal influenza: does the vitamin D status (h)arm the body? // J. Aging Res. — 2012. — Vol. 2012. — Art. 806198.

Stagi S., Bertini F. Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome // Int. J. Pediatr. Otorhinolaryngol. — 2014. — Vol. 78, No.

Amaya-Mejia A. S., O’Farrill-Romanillos P. M., Galindo-Pacheco L. V., Vargas-Ortega G. Mendoza-Zubieta V., Del Rivero-Hernandez L. G., Segura-Mendez N. H. Vitamin D deficiency in patients with common variable immunodeficiency, with autoimmune diseases and bronchiectasis // Rev. Alerg. Mex. — 2013. — Vol. 60, No.

Zakharova I. N., Klimov L. Ya., Kasyanova A. N., et al. The role of antimicrobial peptides and vitamin D in the formation of anti-infective defense // Pediatrics named after G. N. Speransky. — 2017. — Vol. 96, No.

Riverin B. D., Maguire J. L., Li P. Vitamin D supplementation for childhood asthma: a systematic review and meta-analysis // PLoS One. — 2015. — Vol. 10, No.

Man L., Zhang Z., Zhang M., Zhang Y., Li J., Zheng N., Cao Y., Chi M., Chao Y., Huang Q. Song C., Xu B. Association between vitamin D deficiency and insufficiency and the risk of childhood asthma: evidence from a meta-analysis // Int. J. Clin. Exp. Med. — 2015. — Vol. 8 No.

Feng H., Xun P., Pike K., Wills A. K., Chawes B. L., Bisgaard H., Cai W., Wan Y., He K. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: a meta-analysis of birth cohort studies // J. Allergy Clin. Immunol. — 2016. — S0091-6749(16)30960.

Neme A., Nurminen V., Seuter S., Carlberg C. The vitamin D-dependent transcriptome of human monocytes // J. Steroid Biochem. Mol. Biol. — 2016, Nov. — Vol. 164. — P. 180–187. DOI: 10.1016/j.jsbmb.2015.10.018.

Zakharova I. N., Maltsev S. V., Borovik T. E., Yatsyk G. V., Malyavskaya S. I., Vakhlova I. V., Shumatova T. A., Romantsova E. B., Romanyuk F. P., Klimov L. Ya., Elkina T. N. Pirozhkova N. I., Kolesnikova S. M., Kuryaninova V. A., Vasilyeva S. V., Mozzhukhina M. V., Evseeva E. A. Vitamin D deficiency in young children in Russia (results of a multicenter study — winter 2013–2014) // Questions of Pharmacoepidemiology. — 2014. — P. 75–

Jat K. R. Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies // Trop. Doct. — 2017, Jan. — Vol. 47, No.