MODERN METHODS OF EARLY DIAGNOSIS OF INFECTIOUS DERMATOSES
Article Sidebar
Main Article Content
Abstract
Relevance. Infectious dermatoses remain one of the most widespread groups of skin diseases and are characterized by high clinical polymorphism, a tendency towards chronicity and a considerable risk of diagnostic errors in the early stages of the disease. Untimely diagnosis of infectious skin lesions leads to the development of complications, the irrational prescription of therapy and an increase in epidemiological risks, which determines the need to improve modern diagnostic approaches. Aim. Analysis and assessment of modern methods of early diagnosis of infectious dermatoses in order to increase the accuracy and timeliness of making a diagnosis. Materials and methods. An analytical and systematic review of domestic and foreign scientific publications for 2014–2024 was carried out, selected from the PubMed, Scopus, Web of Science, eLIBRARY and Google Scholar databases. Original clinical studies, systematic reviews, meta-analyses and clinical guidelines were included in the analysis. Methods of analysis, systematization and comparative assessment of the diagnostic informativeness of modern laboratory, molecular-genetic and instrumental methods were used. Results. It was established that traditional laboratory methods of diagnosing infectious dermatoses possess limited sensitivity in the early stages of the disease. The greatest diagnostic effectiveness is demonstrated by molecular-genetic methods, which are characterized by high sensitivity and specificity, as well as by non-invasive instrumental methods that make it possible to carry out early differential diagnosis of skin lesions. The most optimal results are achieved with the comprehensive application of clinical assessment together with modern laboratory and instrumental methods of diagnosis. Conclusion. A comprehensive diagnostic approach using modern laboratory, molecular-genetic and instrumental methods makes it possible to increase the accuracy of the early diagnosis of infectious dermatoses, to reduce the frequency of diagnostic errors and to optimize the tactics of patient management.
Article Details
Issue
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
Скрипкин Ю.К., Бутов Ю.С. Кожные и венерические болезни: учебник. – М.: ГЭОТАР-Медиа, 2019. – 544 с.
Кубанова А.А., Кунгуров Н.В., Знаменская Л.Ф. Инфекционные заболевания кожи в практике дерматовенеролога // Вестник дерматологии и венерологии. – 2018. – № 4. – С. 4–12.
Fitzpatrick T.B., Wolff K., Goldsmith L.A. Fitzpatrick’s Dermatology in General Medicine. – New York: McGraw-Hill, 2018. – 3120 p.
World Health Organization. Epidemiology and management of common skin diseases in developing countries. – Geneva: WHO, 2016. – 143 p.
Hay R.J., Johns N.E., Williams H.C. et al. The global burden of skin disease in 2010 // Journal of Investigative Dermatology. – 2014. – Vol. 134, № 6. – P. 1527–1534.
Аравийская Е.Р., Самцов А.В. Инфекционные дерматозы: клиника, диагностика, лечение. – СПб.: СпецЛит, 2017. – 256 с.
Zalaudek I., Lallas A., Argenziano G. Dermoscopy of infectious skin diseases // Dermatologic Clinics. – 2018. – Vol. 36, № 4. – P. 473–485.
Короткий Н.Г., Львов А.Н. Ошибки диагностики инфекционных заболеваний кожи в амбулаторной практике // Клиническая дерматология и венерология. – 2019. – Т. 18, № 2. – С. 87–92.
Ely J.W., Seabury Stone M. The generalized rash: Part I. Differential diagnosis // American Family Physician. – 2010. – Vol. 81, № 6. – P. 726–734.
Ventola C.L. The antibiotic resistance crisis // Pharmacy and Therapeutics. – 2015. – Vol. 40, № 4. – P. 277–283.
Bolognia J.L., Schaffer J.V., Cerroni L. Dermatology. – 4th ed. – Philadelphia: Elsevier, 2018. – 2880 p.
Gupta A.K., Ryder J.E., Nicol K. The use of potassium hydroxide examination in dermatology // Journal of Cutaneous Medicine and Surgery. – 2017. – Vol. 21, № 2. – P. 120–125.
Procop G.W., Church D.L., Hall G.S. Color Atlas and Textbook of Diagnostic Microbiology. – Philadelphia: Lippincott Williams & Wilkins, 2017. – 1568 p.
Caliendo A.M., Gilbert D.N., Ginocchio C.C. et al. Better tests, better care: improved diagnostics for infectious diseases // Clinical Infectious Diseases. – 2013. – Vol. 57, Suppl. 3. – P. S139–S170.
Espy M.J., Uhl J.R., Sloan L.M. et al. Real-time PCR in clinical microbiology // Clinical Microbiology Reviews. – 2006. – Vol. 19, № 1. – P. 165–256.
van Belkum A., Durand G., Peyret M. et al. Rapid clinical bacteriology and its future impact // Annals of Laboratory Medicine. – 2013. – Vol. 33, № 1. – P. 14–27.
Persing D.H. Molecular microbiology: diagnostic principles and practice. – Washington: ASM Press, 2016. – 1450 p.
Longo C., Casari A., Beretti F. et al. Skin infections: diagnostic value of reflectance confocal microscopy // Journal of the European Academy of Dermatology and Venereology. – 2015. – Vol. 29, № 7. – P. 1333–1340.
Argenziano G., Soyer H.P. Dermoscopy of pigmented skin lesions — a valuable tool for early diagnosis // Lancet Oncology. – 2001. – Vol. 2, № 7. – P. 443–449.
Pellacani G., Guitera P., Longo C. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal lesions // Journal of Investigative Dermatology. – 2007. – Vol. 127, № 12. – P. 2759–2765