THE INFLUENCE OF PSYCHOEMOTIONAL STRESS ON THE IMMUNE MECHANISMS OF PSORIASIS DEVELOPMENT

Article Sidebar

PDF (Russian)
Published: 2025-12-05
DOI: https://doi.org/10.66073/researchfocus.v4i11.1872
Keywords:
psoriasis, psycho-emotional stress, neuroendocrine regulation, HPA axis, IL-17A, IL-23, TNF-α, Th17 cells, Substance P, cytokine profile, neurogenic inflammation, clinical activity

Main Article Content

Kurbanov Shaxboz Ilxomovich
Samarkand Regional Branch of the Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology. Uzbekistan, Samarkand, Panjikent street 404
Tolibov Mansur Maxmudovich
Samarkand State Medical University. Uzbekistan, Samarkand, Amir Temur street, 18

Abstract

This study assesses the influence of psycho-emotional stress on the immune mechanisms of the development of psoriasis in order to determine the relationship between stress load, the activation of neuroendocrine pathways and Th17-mediated inflammation. The analysis was carried out by comparing patients with psoriasis who had high and low levels of psycho-emotional stress. On the basis of clinical indices, psychometric scales and immunological indicators, the degree of the influence of stress on disease activity and on specific immune mechanisms was determined. The levels of cortisol, neuropeptides and key pro-inflammatory cytokines and the population of Th17 cells were analysed using correlation analysis. In addition, stable relationships between stress markers and the clinical activity of psoriasis were identified, which is an important indicator for the development of comprehensive psychoimmune therapeutic strategies.

Article Details

Issue

Vol. 4 No. 11 (2025): Research Focus International Scientific Journal. Volume 4, Issue 11 (2025)

Section

14.00.00 – Medical sciences
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

THE INFLUENCE OF PSYCHOEMOTIONAL STRESS ON THE IMMUNE MECHANISMS OF PSORIASIS DEVELOPMENT. (2025). Research Focus International Scientific Journal, 4(11), 314-320. https://doi.org/10.66073/researchfocus.v4i11.1872

References

Rapp SR, Feldman SR, Exum ML, Fleischer AB, Reboussin DM. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41(3 Pt 1):401–7.

de Korte J, Sprangers MA, Mombers FM, Bos JD. Quality of life in psoriasis: A systematic literature review. J Investig Dermatol Symp Proc. 2004;9(2):140–7.

Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu Rev Immunol. 2014;32:227–55.

Boehncke WH, Schön MP. Psoriasis. Lancet. 2015;386(9997):983–94.

Krueger JG, Bowcock AM. Psoriasis pathophysiology: Current concepts of pathogenesis. Ann Rheum Dis. 2005;64(Suppl 2):ii30–6.

Blauvelt A. The IL-23/IL-17 axis in psoriasis pathogenesis. J Dermatolog Treat. 2018;29(1):1–3.

Picardi A, Abeni D. Stressful life events and skin diseases: Diagnostic and therapeutic implications. Psychother Psychosom. 2001;70(3):121–8.

Fortune DG, Richards HL, Griffiths CEM. Psychologic factors in psoriasis: Evidence and clinical implications. Dermatol Clin. 2005;23(4):681–9.

Richards HL, Ray DW, Kirby B, Mason D, Plant D, Main CJ, et al. Response of the hypothalamic–pituitary–adrenal axis to psychological stress in psoriasis. Arch Dermatol. 2006;142(7):885–9.

Chen Y, Lyga J. Brain–skin connection: Stress, inflammation and skin aging. Inflamm Allergy Drug Targets. 2014;13(3):177–90.

Peters EMJ, Arck PC, Paus R. Neuroimmunology of stress: Skin as a model. Brain Behav Immun. 2006;20(4):415–26.

Theoharides TC, Alysandratos KD, Angelidou A, et al. Mast cells and inflammation in skin diseases. Front Immunol. 2018;9:1279.

Harvima IT, Nilsson G, Naukkarinen A. Neuroimmune connections in psoriasis: Nerve growth factor, substance P and mast cells. Exp Dermatol. 2021;30(1):11–21.

Pincelli C. Nerve growth factor and keratinocytes: Regulation of growth and apoptosis. Arch Dermatol Res. 2000;292(11):533–6.

Buske‐Kirschbaum A, Ebrecht M, Hellhammer DH. Blunted cortisol responses to psychosocial stress in patients with atopic dermatitis. Psychother Psychosom. 2010;79(1):39–42.

Harden JL, Krueger JG, Bowcock AM. The immunopathogenesis of psoriasis: Genetic, environmental and immunologic triggers. Semin Immunopathol. 2015;37(3):307–20.

Tausk FA, Whitmore SE, Eskin BA. Stress and the skin. Int J Dermatol. 2001;40(9):627–31.

Kim N, Cho YS. Neurogenic inflammation and skin disorders: IL-17/IL-23 and neuropeptide pathways. Exp Dermatol. 2017;26(6):597–604.